PLX047500

GSE134641: In vitro transcriptomic responses to thioacetamide-S-oxide exposure in human primary hepatocytes, renal tube epithelial, and cardiomyocytes

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In this study we tested the ability to predict organ injury endpoints from in vitro transcriptomics responses at early time points (9 and 24 hours) after to thioacetamide-S-oxide treatment, the toxic metabolite of thioacetamide. Thioacetamide, an organosulfur compound, have been extensively used in animal studies as a hepatotoxin and carcinogen for its ability to cause acute liver damage. SOURCE: Patric Schyman (pschyman@bhsai.org) - Biotechnology HPC Software Applications Institute (BHSAI)

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