PLX291922

GSE134439: Mapping Gata2 enhancer-dependent developmental trajectories by single-cell RNA-sequencing

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We compared single-cell transcriptomes of fetal liver myeloid progenitor pools (CMP/GMP pool) from Gata2 -77 enhancer mutant embryos and wildtype littermates. Gene expression patterns in -77-deficient mice demonstrated loss of erythroid, megakaryocyte and granulocyte progenitors and an increase in monocyte SOURCE: Emery Bresnick (dconn2@wisc.edu) - Bresnick Lab University of Wisconsin-Madison

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