PLX275079

GSE133160: The oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

We show that NRF2 activation drives hepatocellular carcinoma development in vivo. Moreover, NRF2 undergoes glucose dependent modification called glycation and requires the de-glycating enzyme FN3K to maintain NRF2' oncogenic functions. SOURCE: Viraj Sanghvi (sanghviv@mskcc.org) - Wendel lab MSKCC

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