PLX006440

GSE132091: Toxoplasma gondii infection of human retinal pigment epithelial cells

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We performed RNA-Sequencing (RNA-Seq) of primary human retinal pigment epithelial cells and the ARPE-19 cell line 24 hours following infection with GT-1 strain T. gondii tachyzoites. Gene ontology and pathway enrichment analyses of differentially expressed total RNA identified a strong immunologic transcriptomic signature. There were limited changes in the small RNA transcriptome. We used RT-qPCR for 26 immune response-related protein-coding and long non-coding transcripts in different primary epithelial cell isolates to confirm immunological activity of infected cells. SOURCE: Justine Smith Flinders University

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