PLX285532

GSE131942: Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Mutations/deletions of BAP1, CDKN2A, and NF2 are the most frequent genetic lesions in human MM. We introduced various combinations of these deletions in the pleura of conditional knockout (CKO) mice, focusing on the contribution of Bap1 loss. SOURCE: yinfei tan (Yinfei.Tan@fccc.edu) - NGS-research Fox Chase Cancer Center

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