PLX278818

GSE130313: Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Epigenetic activation of an enhancer for TGFB2 locks SSc patient fibroblasts into a pro-fibrotic synthetic state through mechanisms dependent on NF-kB and BRD4. SOURCE: Joseph,Y,Shin (jshin50@jhmi.edu) - Johns Hopkins University School of Medicine

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