PLX195408

GSE129975: Atrx deletion in neurons leads to sexually-dimorphic dysregulation of miR-137 and spatial learning and memory deficits

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Ablation of the ATRX chromatin remodeler specifically in forebrain excitatory neurons of mice causes male-specific deficits in long-term spatial memory associated with miR-137 overexpression, transcriptional changes and structural alterations corresponding to pre- and post-synaptic abnormalities. SOURCE: Vanessa Dumeaux (vanessadumeaux@gmail.com) - Concordia University

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