PLX052341

GSE129412: The effects of TBBPA/TBBPS/TCBPA on human hepatic development

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We evaluated the hepatic developmental toxicity of TBBPA/TBBPS/TCBPA with a human embryonic stem cells (hESC) system. We found that TBBPA/TBBPS/TCBPA might adversely affect human hepatocyte-like cells specification from hESCs via mainly impairing definitive endoderm specifications, suggesting the early stages of embryonic development are susceptible to the three compounds. SOURCE: Shaojun Liang (liangshaojun1989@126.com) - Chinese academy of sciences

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