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PLX204920
GSE128730: RNAseq of parental and neratinib resistant 5637 and OVCAR8 cells with or withour neratinib treatment
- Organsim human
- Type RNASEQ
- Target gene
- Project ARCHS4
Pan-HER TKI neratinib has demonstrated clinical activity in patients with HER2-mutant cancers. However responses are heterogenoeus and not generally prolonged, suggesting de-novo and acquired resistance to neratinib. To study mechanisms of resistance to neratinib we generated neratinib resistant cells by gradual dose escalation until resistance was achieved and performed various analyses including RNAseq. SOURCE: Dhivya Sudhan (Dhivya.Sudhan@UTSouthwestern.edu) - Vanderbilt University
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