PLX184680

GSE128696: Gene expression comparison of resting human peripheral-blood NK cells and activated counterparts

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Resting NK cells are notoriously difficult to transduce, especially using the VSVG lentivirus pseudotype. When NK cells are expanded and activated using the NKAES system, there is a modest improvement of transduction rates compared to their resting NK counterparts. Still, the transduction efficiency remains poor for robust development of NK cell-based cancer immunotherapy. We envisaged to have a genome-wide expression profile of resting and activated NK (NKAES) cells in order to improve currrent transduction protocols . SOURCE: Panojot Bifsha (panojot.bifsha@gmail.com) - CHU Sainte-Justine

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