PLX032602

GSE127172: Gene expression profiles of mouse colonic epithelial monolayer cultured in air-liquid interface

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. Our understanding of how this process occurs is limited by a lack of in vitro models that recapitulate key aspects of in vivo responses. We established a long-term, self-organizing 2D epithelial monolayer system to model the cyclic nature of epithelial alterations during injury-repair. Through RNA-seq analysis, we seek to evaluate the transcriptomic profiles of the cultured epithelial cells under select phases of homeostasis-injury-repair in vitro. SOURCE: Thaddeus Stappnbeck (stappenb@wustl.edu) - Washington University School of Medicine