PLX027233

GSE126981: Effect of Salmeterol and Roflumilast N-oxide (RNO) alone and in combination on gene expression changes in BEAS-2B human airway epithelial cell line

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

RNA-sequencing was performed to study the effect of phosphodiesterase 4 inhibition by Roflumilast N-oxide (RNO) on gene expression changes produced by sub-maximal concentrations of the long acting 2-adrenoceptor agonist, Salmeterol. Our results indicate that RNO enhanced the expression of all salmeterol-regulated genes, but the degree of enhancement varied between genes due to the difference in their sensitivities to salmeterol. SOURCE: Radhika Joshi (radhika.joshi@ucalgary.ca) - University of Calgary

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