PLX030190

GSE126957: The regeneration transcriptome of corticospinal neurons

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In the present study, we identify transcriptional mechanisms associated with corticospinal regeneration. We took advantage of the ability of NPC grafts to support corticospinal regeneration, together with a genetic mouse model (Glt25d2-GFP-L10a mice, in which a bacterial artificial chromosome (BAC) codes for GFP-tagged polyribosomes in layer 5b cortical neurons) to selectively enrich actively translated mRNA pools from layer Vb cortical projection neurons containing corticospinal neurons (Doyle et al., Cell 2008). SOURCE: Riki Kawaguchi (rkawaguchi@mednet.ucla.edu) - Giovanni Coppola, Informatics Center for Neurogenetics and Neurogenomics (ICNN). University of California Los Angeles

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