PLX261151

GSE126402: Negative regulation of lymphoid specification by the transcription factor TAL1

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Lymphoid primed multipotent progenitors are a subset of MPPs that are undergoing specification to the lymphoid and myeloid cell fates. The transcription factors Lyl1 and E2A are both essential for the development LMPPs and can form a heterodimeric complex. We examined the consequences of E2A- or Lyl1-deficiency on development of LMPPs and on their gene expression program in comparison with wild-type LMPPs SOURCE: Barbara,L,Kee The University of Chicago

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