PLX242132

GSE126345: Transcriptome analysis of different brain areas in Hcrt gene and Hcrt cell ablated mice

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Hypocretin (HCRT) and melanin concentrating hormone (MCH) are brain neuropeptides regulating a wide range of functions including sleep and metabolism. Loss of function of HCRT causes the sleep disorder narcolepsy. We found that loss of HCRT neurons in Hcrt-ataxin-3 mice results in a specific 50% decrease in another orexigenic neuropeptide QRFP that might explain the metabolic syndrome in narcolepsy. SOURCE: Sylvain Pradervand (Sylvain.Pradervand@unil.ch) - DNA Array Facility UNI Lausanne

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