PLX112427

GSE126068: Heterogeneity and evolution in acute myeloid leukemia initiating cells

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Little is currently known about the heterogeneity of leukemic initiating cells and how they evolve during AML disease progression. AML exhibits extremely few DNA mutations (an average of 13 per patient); therefore, it is likely that RNA based changes also play crucial roles in the development and progression of AML. We have optimized a method to robustly and cost-effectively perform single cell RNA sequencing on AML initiating cells (CD34+CD38-CD45RA+CD90-Lin-7AAD-). We completed a study on serial diagnosis/relapse samples from five AML patients, which revealed strong evidence of the evolution of RNA based changes in AML initiating cells. SOURCE: David Wald (dnw@case.edu) - Case Western Reserve University

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