PLX167484

GSE123357: Mouse Estrogen Treatment Study Analysis of Peri-prostatic Fat

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Obesity is associated with an increased incidence of high grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was associated with high grade PC. Possibly, interventions that suppress periprostatic WAT inflammation will improve outcomes for men with PC. Here, we tested the hypothesis that supplemental 17-estradiol (E2) could decrease periprostatic WAT inflammation in obese male mice. SOURCE: Akanksha Verma (akv3001@med.cornell.edu) - Weill Cornell Medical College

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