PLX067912

GSE123117: Gene expression profile in Liver of old mice after 5 weeks of Heterocronic parabiosis with Yg WT or Yg MANFHet mice

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

To ask whether MANF contributes to the rejuvenating effects of heterochronic parabiosis, we generated heterochronic pairs in which 20 month old WT mice were combined with either 4 month old MANFHet (O-YgHet) or WT (O-YgWT) littermates, and maintained for 5 weeks before analysis. Control pairs in which old WT mice were combined together (O-O) were used. Livers were collected from each animal in the pair and RNA was sequenced for 5 independent animals/condition. SOURCE: Pedro Sousa-Victor (pvictor@buckinstitute.org) - Jasper Lab Buck Institute for Research on Aging