PLX251313

GSE121480: RNA-seq of bulk Treg and Tconv cells from murine liver and lymphoid tissues

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

With the aim of understanding how Treg cells in highly vascularized tissues are related to Treg cells in other organs, we performed RNA-seq analysis of bulk Treg and Tconv cells isolated from liver, blood, spleen, and the liver-draining portal lymph node. This revealed a clear separation of cell transcriptomes by both tissue and Treg/Tconv identity, with cells from the liver falling between blood- and spleen-derived cells. Compared to splenic Treg cells, hepatic Treg cells were enriched for genes related to proliferation and activation, and genes encoding chemokine and cytokine receptors. SOURCE: Alexander,Y,Rudensky Memorial Sloan Kettering Cancer Center

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