PLX029634

GSE119584: Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediate DNA Damage Response [bulk RNA-seq]

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We evaluated transcriptional changes elicited by targeting AAVS1 and IL2RG genes and we found that the impact of one or few nuclease-induced DNA DSBs is minor and mainly limited to genes belonging to the p53 pathway. The same pathway was elicited by gene editing at two distinct genomic loci and was more pronounced in primitive vs. progenitor cells. SOURCE: Ivan Merelli (ivan.merelli@itb.cnr.it) - CNR-ITB

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