PLX062522

GSE119331: Molecular Pathology of adverse local tissue reaction caused by metal-on-metal implants

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

RNA-sequencing analysis of periacetabular synovial tissue collected from patients undergoing a revision total hip arthroplasty (rTHA) after failure of a Cobalt Chromium implant. Comparisons were made to periacetabular synovial tissue collected from patients undergoing primary THAs (pTHA).; Results: Analysis of tissue biopsies by RNA-sequencing revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. SOURCE: Asha Nair (nair.asha@mayo.edu) - Mayo Clinic

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