PLX248599

GSE118933: Immune Checkpoint Regulation of Pulmonary Fibrosis [bulk RNA-seq]

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Fibroblasts from idiopathic pulmonary fibrosis (IPF) patients acquire an invasive phenotype that is essential for progressive fibrosis. The immune checkpoint ligand CD274 (PD-L1) is up-regulated on invasive lung fibroblasts, regulated by P53 and FAK signaling, and drives lung fibrosis in a humanized IPF model in mice. Targeting CD274high fibroblasts blunted invasion in vitro and attenuated fibrosis in vivo, suggesting that CD274 may be a novel therapeutic target in IPF. SOURCE: yizhou wang (yizhou.wang@cshs.org) - cedars sinai medical center

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