PLX244702

GSE118766: Activation of a novel ULK1-MLK3-ERK5 pathway by the IFNg receptor is required for IFNg-inducible antiviral responses

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Although well established that signal transducer and activator of transcription 1 (STAT1) activation is required for an interferon (IFN)-mediated antiviral response, the potential roles of other IFNg-activated cellular pathways in the process are unknown. We provide evidence that Unc-51-like kinase 1 (ULK1) is activated during engagement of the Type II IFN receptor and is required for IFNg-mediated transcription of key interferon stimulated genes involved in anti-viral and innate immune responses. SOURCE: Diana SaleiroPlatanias Robert H. Lurie Comprehensive Cancer Center

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