PLX229499

GSE118089: Complement C5a/C5a receptor 1 induces renal injury in diabetic kidney disease via mitochondrial metabolic reprogramming

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In mice, complement C5a and its receptor C5aR1 elicit systemic and local inflammation and drive tissue injury in diabetic kidney disease via altered metabolic flexibility, which can be attenuated by therapy with a specific orally active inhibitor of C5aR1. SOURCE: Mark,D,Ziemann (mark.ziemann@gmail.com) - Deakin University

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