PLX171727

GSE117699: p38 SAPK and SKIIP induced changes in alternative splicing patterns upon osmostress

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Alternative splicing is a crucial mechanism for gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps of mRNA biogenesis. Here, we show that osmostress has a major impact on the regulation of alternative splicing (AS), which is partly mediated through the action of the p38 SAPK. Remarkably, a splicing network analysis revealed a functional connection between p38 and the spliceosome component SKIIP. Depletion of SKIIP abolished a significant part of the p38-mediated alternative splicing. SOURCE: Francesc Posas Cell Signaling Group, Universitat Pompeu Fabra

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