PLX172246

GSE117655: HIV-1 Vpu exerts broad immunosuppressive effects by inhibiting NF-B-dependent gene expression

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Using an unbiased RNA sequencing approach of primary CD4+ T cells infected with three wild type primary HIV-1 isolates and selective mutants thereof, Langer et al. show that the HIV-1 accessory protein Vpu exerts broad immunosuppressive effects, inhibiting the induction of innate and adaptive immune responses. Transcription factor network analyses reveal that Vpu suppresses the expression of NFB rather than IRF3 target genes. As a result, Vpu impairs the production of pro-inflammatory cytokines such as IFN, CXCL10 and IL-6. SOURCE: Lars Pache Sanford Burnham Prebys Medical Discovery Institute