PLX026432
GSE117608: Long non-coding RNA SMILR regulates genes involved in cytokinesis in human vascular smooth muscle cell
- Organsim human
- Type RNASEQ
- Target gene
- Project ARCHS4
In response to blood vessel wall injury, aberrant proliferation of vascular smooth muscle cells causes pathological remodelling. The controlling mechanisms involved are, however, not completely understood. We recently showed that the intergenic human, poorly-conserved long non-coding RNA, SMILR, promotes vSMC proliferation. Here, using deep RNA-sequencing of vSMCs with SMILR knockdown or overexpression, we identified an interconnected cell cycle network controlled by SMILR. SMILR inhibition led to vSMC binucleation and mitotic arrest. SOURCE: Julie,mesenchymal,Rodor (Julie.Rodor@ed.ac.uk) - UNIVERSITY OF EDINBURGH
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