PLX172590

GSE117483: RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

The NOTCH1-driven MYC enhancer (NMe) is essential for T cell development, transformation and the development of acute lymphoblastic leukemia. Here we analyze by RNAseq the gene expression profile of DN3 thymocytes from NMe wild type and NMe GATA site 1 and 2 (GS1+2) homozygous mutant mice. GSEA analysis show a significant enrichment of MYC signature genes, consistent with a deficient function of NMe in GATA site 1 and 2 homozygous mutant thymocytes. SOURCE: Stuart,Aidan,Quinn (saq2106@columbia.edu) - Adolfo Ferrando Columbia University

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