PLX228234

GSE115187: Gene expression changes in Ing1- and Gadd45a- single- or double-knockout mouse embryonic fibroblasts

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We previously found that ING1b is required to target GADD45a-mediated active DNA-demethylation via TET1 to specific loci. In order to study the impact of ING1-GADD45a on gene expression, we compared the expression profile of wildtype mouse embryonic fibroblasts (MEFs) with Ing1- and Gadd45a- single- or double-knockout (DKO) MEFs. SOURCE: Emil Karaulanov (e.karaulanov@imb-mainz.de) - Institute of Molecular Biology

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