PLX225281

GSE115112: Estrogen responsive transcriptome of estrogen receptor positive normal human breast cells in 3D cultures

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Understanding how differentiation, microenvironment, and hormonal milieu influence human breast cell susceptibility to malignant transformation will require the use of physiologically relevant in vitro systems. We developed a 3D culture model that enables the propagation of normal estrogen receptor alpha (ER)+ cells. The purpose of this experiment was to assess ER functionality and compare estrogen-induced transcripts among samples and systems. SOURCE: Paul Yaswen (P_Yaswen@lbl.gov) - LBNL

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