PLX053709

GSE114502: Altered mRNA splicing by mutant p53 activates oncogenic RAS in pancreatic cancer

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Integrating transcriptomic analyses of both clinical PDAC and PDAC models, we identified that the most common neomorphic TP53 mutation (p53R175H) rewires RNA splicing promoting transcriptome-wide retention of cassette exons bearing cytosine(C)-rich sequences. SOURCE: Luisa,Fernanda,Escobar Hoyos (escobarl@mskcc.org) - Memorial Sloan Kettering Cancer Center

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