PLX167442

GSE114067: Tissue tuft cell mRNA sequencing

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

The goal of the study was to sequence mRNA from tuft cells (identified as CD45-;EpCAM+;IL-25+ using Flare25 reporter mice) in the epithelia of 5 different murine tissues: trachea, thymus, colon, gall baldder, small intestine. As a control, non-tuft epithelial cells (CD45-;EpCAM+;IL-25-) were also isolated. The data were used to identify differentially expressed genes across tuft cells from different tissues and to define a transcriptional tuft cell "signature" that is common to all tissues analyzed but absent in the non-tuft epithelial cells. SOURCE: Joshua Pollack (joshua.pollack@ucsf.edu) - UCSF

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