PLX174667

GSE113855: Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Here we demonstrate that the neurovasculature exhibits a unique transcriptional signature following inflammatory insults, and pharmacological inhibition of monoacylglycerol lipase using a newly characterized inhibitor, rescues the transcriptional profile of brain vasculature, and restores its functional homeostasis. SOURCE: Jie Quan (jie.quan@pfizer.com) - Pfizer

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