PLX153413

GSE113594: Distinct macrophage populations upon physiological changes in adipose tissue [RNA-seq]

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We report that obese fat tissue of mice contain multiple distinct populations of adipose tissue macrophage (ATM) with unique transcriptomes and chromatin landscapes. Mouse Ly6c ATMs express genes that are adipogenic, while CD9 ATMs express pro-inflammatory genes under the control of activating transcription factors. Adoptive transfer of Ly6c ATMs into lean mice activates gene programs typical of normal adipocyte physiology. By contrast, adoptive transfer of CD9 ATMs drives gene expression that is characteristic of obesity. SOURCE: Hee-Woong Lim University of Pennsylvania

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