PLX208042

GSE112607: To determine the potential molecular mechanisms by which STAT5 signaling controls colonic crypt homeostasis, we isolated total RNA from ileal intact crypts of STAT5+/+, STAT5DIEC-/- and STAT5DIEC+++ mice and performed RNA sequencing (RNA-seq).

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Reads were aligned to the mm10 genome with annotations provided by Ensembl. Transcripts were filtered, requiring at least 3 reads in 50% of samples within at least one condition. To identify differentially-regulated transcripts, we performed ANOVA (FDR-corrected p<0.05) and required the fold change to exceed 1.5. SOURCE: Rebekah Karns (Rebekah.Karns@cchmc.org) - Cincinnati Children's Hospital Medical Center

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