PLX179588

GSE112155: RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We compared the transcriptome of keratoconus and control epithelium using RNA-Seq. Epithelial tissues were obtained prior to surgery from keratoconus and myopia control patients, undergoing collagen cross-linking and photorefractive keratectomy, respectively. We identified major differences in keratoconus linked to cell-cell communication, cell signalling and cellular metabolism. The genes associated with the Hedgehog, Wnt and Notch1 signaling pathways were down-regulated in keratoconus. SOURCE: Susan Corley (s.corley@unsw.edu.au) - Systems Biology Initiative UNSW

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