PLX179588

GSE112155: RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

We compared the transcriptome of keratoconus and control epithelium using RNA-Seq. Epithelial tissues were obtained prior to surgery from keratoconus and myopia control patients, undergoing collagen cross-linking and photorefractive keratectomy, respectively. We identified major differences in keratoconus linked to cell-cell communication, cell signalling and cellular metabolism. The genes associated with the Hedgehog, Wnt and Notch1 signaling pathways were down-regulated in keratoconus. SOURCE: Susan Corley (s.corley@unsw.edu.au) - Systems Biology Initiative UNSW

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