PLX187738
GSE111753: Gene expression profiling of neural crest cells from E10.5 mouse embryos with basal p53 or activated p53
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
To investigate the mechanisms by which p53 activation triggers developmental defects, we generated a mouse model in which p53 is activated in neural crest cells due to the expression of a mutant p53 protein (p53-25,26) that can bind to and stabilize wild-type p53. Here, we performed gene expression profiling on neural crest cells isolated from these embryos, to identify the transcriptional response to p53 activation during embryogenesis. SOURCE: Margot,Elizabeth,BowenLaura Attardi Stanford University
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