PLX109168

GSE110703: Uncoupling of transcription and cytodifferentiation in mouse spermatocytes with impaired meiosis

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

We use the cytologically well-defined Prdm9 mutant mouse as a model of developmental arrest to demonstrate that parallel programs of cellular differentiation and transcription can become dis-associated. By comparing cytological phenotype markers and transcriptomes in wild-type and mutant spermatocytes, we identified multiple instances of cellular and transcriptional uncoupling in Prdm9-/- mutants. SOURCE: Gregory Carter (Gregory.Carter@jax.org) - The Jackson Laboratory

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