PLX110916

GSE110680: Inhibiting WNT and NOTCH in renal cancer stem cells: implications for human patients

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

We detected and characterized CXCR4+MET+CD44+ cancer stem cells (CSCs) that were quantitatively correlated with aggressive tumors. Transcriptional profiling and single-cell sequencing revealed a strong activation of WNT and NOTCH signaling in these CSCs. CEL-Seq was performed to study heterogeneity of the CXCR4+MET+CD44+ population. SOURCE: Annika Fendler (annika.fendler@mdc-berlin.de) - Max Delbrueck Center for Molecular Medicine in the Helmholtz Association

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