PLX161588

GSE109936: Establishment of novel atopic dermatitis model by Nestin-cre mediated Ikk2 deficiency

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

To generate novel atopic dermatitis model, we used Nestin-cre mediated Ikk2FL/FL mice. Nestincre-mediated conditional knockout mice of Ikk2 gene were generated by crossing female Ikk2FL/FL mice to male Nestin-cre;Ikk2FL/+mice. Nestin-cre;Ikk2FL/FL mice spontaneously develop chronic AD-like skin inflammation and severe pruritus. We further performed Cap analysis of gene expression (CAGE) to elucidate transcriptional profiles in lesional skin of Nestin-cre;Ikk2FL/FL mice. SOURCE: Satoshi Nunomura (nunomura@cc.saga-u.ac.jp) - Izuhara lab Saga Medical School

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