PLX098487

GSE109279: Small molecule screen identifies de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, we performed a small molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss. SOURCE: Karina,Noemi,Gonzalez Herrera (knherrer@fas.harvard.edu) - Haigis Lab Harvard Medical School

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