PLX069763

GSE107919: Chromatin remodeler CHD8 in CNS myelination and remyelination

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Mutations in CHD8, an ATP-dependent chromodomain-helicase-DNA-binding protein 8, are known to cause a set of Autism Spectrum Disorders (ASD). We found that CHD8 is highly expressed in myelinating oligodendrocytes (OL) and their progenitors in the developing central nervous system (CNS).We performed CHD8 chIP-seq analysis in cultured oligodendrocytes. SOURCE: Richard LuLu Lab,T6.525 Cincinnati Children's Hospital Medical Center

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