PLX072699

GSE107590: Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Tamoxifen resistant translational reprogramming is shown to be mediated by increased expression of eIF4E and its increased availability by hyperactive mTOR, and to require phosphorylation of eIF4E at Ser209 by increased MNK activity. SOURCE: Robert,J,Schneider (robert.schneider@nyumc.org) - NYU School of Medicine

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