PLX300021

GSE106389: RNAseq anaysis of ventral striatum cholinergic cells of p11 cKO mice

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Purpose: To identify gene expression changes in cholinergic neurons of the ventral striatum of p11 cKO mice; Method: Translating Ribosome Affinity Purification (TRAP) to isolate RNA from ChAT+ cells and, cDNA synthesisi and next generation RNAseq using Illumina Hiseq sequencer.; Results: Biostatistical analysis identified 113 genes that were altered by p11. 59 genes were up-regulated and 54 down-regulated. SOURCE: Yotam Sagi Rockefeller University

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