PLX291591

GSE106246: An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

mRNA quality control mechanisms ensure fidelity of protein translation. An evolutionarily conserved component of the quality control machinery, Dom34/Pelota (Pelo), rescues stalled ribosomes. Here we show that Pelo is required for mammalian epidermal homeostasis. Our study reveals a novel role for the ribosome-rescue machinery in mammalian tissue homeostasis and an unanticipated specificity in its impact on different stem cell populations. SOURCE: Fiona,M,Watt (fiona.watt@kcl.ac.uk) - King's College London

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