PLX105748

GSE104174: Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Integration of differential expression (DE) and expression QTL (eQTL) analysis in monocyte-derived macrophages (MDMs) from systemic sclerosis (SSc) patients and healthy controls reveals (i) changes in macrophage transcriptome as an important contributor in SSc and (ii) cis-regulation in GSDMA as a disease risk in macrophages, but not skin. SOURCE: Aida Moreno-Moral Duke-NUS Medical School

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