PLX139090

GSE103844: RORt and ROR Signature Genes in Human Th17 Cells

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

In an effort to study gene expression modulated by RORt and ROR in human Th17 cells, global gene expression of human CD4 T cells activated under Th17 skewing conditions was profiled by RNA sequencing. RORt and ROR signature genes were identified in these Th17 cells treated with specific siRNAs to knock down RORt or ROR expression. In addition, selective small molecule RORt modulators were also utilized as pharmacological tools in RORt signature gene identification. SOURCE: Xuejun Liu (xliu3@its.jnj.com) - Janssen Research & Development, LLC

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