PLX164438

GSE103520: Transcriptome-wide response to synthetic chromatin protein PcTF

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

The goal of this study was to identify genes that become upregulated in response to a synthetic transcription factor, PcTF, in a panel of breast cancer model cell lines. PcTF contains a conserved H3K27me3-binding chromodomain expressed in-frame with an mCherry fluorescent tag and a VP64 activation domain. Therefore, we expected genes with H3K27me3-associated promoters to become upregulated upon PcTF expression. We observed that hundreds of genes became up or downregulated. SOURCE: Karmella Haynes (Karmella.Haynes@asu.edu) - Haynes Arizona State University

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