PLX273095

GSE100882: SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia [RNA-seq]

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

We identified novel recurrent genetic lesions in T-PLL affecting genes involved in JAK/STAT signaling (PTPRC), epigenetic regulation (PRDM2), or DNA damage repair (SAMHD1, PARP10, HERC1, HERC2). Mutations of the tumor suppressor gene SAMHD1 causing amino-acid exchanges or protein truncations as well as copy number variations in SAMHD1 were seen in 20% of cases. SOURCE: Ludger Klein-Hitpass (ludger.klein-hitpass@uni-essen.de) - BioChip Lab Institut fuer Zellbiologie

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