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Sequencing-based assays (Page 94)
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GSE134493: Next Generation Sequencing Facilitates Quantitative Analysis of ADORA1 knockdown and scrambled-shRNA control cells' Transcriptomes
Expression profiles of ADORA1-shRNA-transfected Sk-mel-28 human melanoma cell line and scrambled-shR...
GSE134802: A male infertility mutation switches NANOS1 activity from anti-apoptotic to pro-apoptotic
While Nanos-mediated maintenance of germ cells in Drosophila and mice has been related to regulation...
GSE135219: Transcriptome analysis of CHI3L1 knockdown NP cells
Intervertebral disc degeneration is the main cause of low back pain and the mechanism of which is fa...
GSE135803: Transcriptomics of human macrophages upon infection with Legionella pneumophila and two isogenic mutants, LamA and AnkH using RNA-seq
The objective of this study is to determine changes in the global transcriptome of human macrophages...
GSE126580: Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2
Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in th...
GSE136437: A comparison of evolutionary changes and constraints on gene regulation between fin and limb development [RNA-seq]
We report time-series transcriptome of developing bamboo shark fin buds and mouse forelimb buds, and...
GSE134472: RNA-seq in putamen of Multiple system atrophy patients
We performed RNA-seq on total RNA from tissue samples from putamen of the brain from Multiple system...
GSE135288: Lamin A/C regulates lncRNAs and epigenetic network in the heart
Mutations in Lamin A/C (LMNA) cause a heterogeneous group of genetic disorders named as laminopathie...
GSE137153: Regional specificity of gene expression in dopaminoceptive neurons
Cell types are defined by their patterns of gene expression. Forebrain dopaminoceptive neurons play ...
GSE135008: Gene expression profiles of MLL-AF9 leukemia cells treated with DS-5272
To assess the molecular changes induced by p53 activation in MLL-AF9 leukemia, we examined gene expr...
GSE135044: Transcriptional Profile of Col1a1GFP+ CNS cells in health and EAE
Bulk RNA Sequencing of Col1a1GFP+ cells from the spinal cords of healthy Col1a1GFP mice and mice 5 o...
GSE125603: Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset
About one third of dilated cardiomyopathy (DCM) cases are caused by mutations in sarcomere or cytosk...
GSE138445: Comparing the transcriptome of nave C57BL/6 CD44+/+ vs CD44-/- alveolar macrophages
Purpose: Determine if alveolar macrophage express different transcriptional programs when CD44 expre...
GSE137186: Human bone marrow-derived mesenchymal stromal/stem cells retain their trophic repair and immunoregulatory properties but lose their multipotent differentiation capacity after extensive ageing in vitro
To assess the hierarchical importance of multipotent differentiation compared with trophic/immunoreg...
GSE134803: Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple negative breast cancer progression
Purpose: To investigate the impact of ASAP1 depletion on the transcriptomic profile of TNBC cells us...
GSE125877: Stk40 deletion elevates c-JUN protein level and impairs mesoderm differentiation
Mesoderm development is a finely tuned process initiated by the differentiation of pluripotent epibl...
GSE139493: Transcriptional analysis of tendons from mice with a targeted deletion of scleraxis
We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 backgroun...
GSE137827: RNA Sequencing Analysis of macrophages from Wild Type and Gsdmd-/- colitis mice
We identified that GSDMD protected against DDS-induced colitis, and GSDMD deficiency in macrophages ...
GSE135251: TRANSCRIPTOMIC PROFILING ACROSS THE SPECTRUM OF NON-ALCOHOLIC FATTY LIVER DISEASE
The pathophysiological mechanisms that drive non-alcoholic fatty liver disease (NAFLD) progression r...
GSE134463: Gene Network Transitions in Embryos Depend Upon Interactions between a Pioneer Transcription Factor and Core Histones [RNA-Seq]
Gene network transitions in embryos and fate-changing contexts involve combinations of transcription...
GSE125708: Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain stuied at single-cell resolution
The mammalian central nervous system (CNS) is capable of tolerating chronic hypoxia, but cell type-s...
GSE137800: Effect of ionizing radiation on transcriptome during neural differentiation of hESC
Differentiation of hESCs to neural lineages was used as a model for early embryonic brain developmen...
GSE139935: RNA sequencing of tissue resident macrophages, progenitors and tumor cells from murine head and neck tumors
We report the RNA sequences of bone marrow derived and tissue resident macrophages and their progeni...
GSE126860: Transcriptome analysis of ACKR3+ and ACKR3- Marginal Zone B cells (MZBs) in mice
The marginal zone (MZ) of the spleen contains a specialized set of innate-like B cells that are in d...
GSE134298: Redefining the nucleosomal architecture of active and inactive promoters in the context of cellular plasticity and cancerr (RNA-seq)
We employed an MNase-Transcription Start Site Sequence Capture method to map and determine the acces...
GSE145639: Epigenetic therapy induces transcription of Inverted SINEs and ADAR1 dependency
In this study we show that intronic and intergenic SINE elements, specifically inverted repeats (IR)...
GSE135229: ETS family proteins bind glucocorticoid receptor: relevance for treatment of Ewing sarcoma
Differential expression of gene was analyzed after FLI1 silencing in Ewing Sarcoma cell line A673. S...
GSE148275: Transcriptiomics profiling of brown adipose tissue of adipocyte-specific Beclin1 knockout mice
Adipose mRNA profiles of wildetype and Beclin1 knockout (tamoxifen-induced Adipoq-CreER/Beclin1(flox...
GSE141048: Trancriptomics of primary human monocytes and monocyte-derived Langerhans cells (moLC)
We propose a novel method of generating Langehans cell in culture. This sequencing dataset was produ...
GSE134506: Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (A...
GSE141119: PD-1 and TIGIT co-expression identifies a circulating CD8 T cell population predictive of response to anti-PD-1 therapy in melanoma and Merkel-cell carcinoma patients [RNA-seq]
Clinical benefit from PD-1 inhibitors relies on reinvigoration of endogenous anti-tumor immunity. Ef...
GSE134988: H2A.Z Facilitates Licensing and Activation of Early Replication Origins
DNA replication is a tightly regulated process that ensures the precise duplication of the genome du...
GSE135264: GEF-H1 mediated gene expression changes in BMDCs in response to microtubule destabilization
GEF-H1 controls transcriptional programs that mediate antitumor immuity upon microtubule destabiliza...
GSE145950: Comparative evaluation of metabolic, electrophilic, and immunologic effects of itaconate and its ester derivatives on macrophage activation
Itaconate is a metabolite naturally produced in large amounts in macrophages after exposure to immun...
GSE143318: RNAseq analysis highlights significant transcriptional changes within the livers of patients with alcoholic hepatitis.
Alcoholic hepatitis (AH) is frequently a severe clinical condition associated with high short-term m...
GSE134536: Transcriptional profiling of CD45RO+CD57+CD4+ T cells
RNA-seq data to examine transcriptiome of CD57+ versus CD57- memory CD4+ T cells SOURCE: Paul Klener...
GSE125688: Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for...
GSE134515: Transcriptomic analysis of Sh2d2a knockout regulatory T cells following a time-course of anti-CD3 stimulation
We report that the T cell specific adaptor protein (TSAd, encoded by the Sh2d2a gene) serves as a cr...
GSE136533: RNA-seq analysis of control and ZC3H18-depleted ovarian cancer cells
We report the differential gene expression in control versus ZC3H18-depleted OVCAR-8 cells SOURCE: D...
GSE142378: Diversification of posterior Hox patterning by graded ability to engage inaccessible chromatin [RNA-seq]
While Hox genes encode for similar transcription factors (TFs), they induce different fates across b...
GSE125685: RNA-seq analysis of FACS-sorted control and Tsc2 cKO nociceptors with and without sciatic nerve crush
The goals of this study are to compare the transcriptomes of control heterozygous and Tuberous scler...
GSE134329: RNA seq analysis of human macrophages after treatment of glimepiride versus empagliflozin.
Purpose: The goal of this study is to compare NGS-derived macrophage transcriptome profiling (RNA-se...
GSE137819: Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions
Macrophage heterogeneity within atherosclerotic plaques was explored with intravital imaging, flow c...
GSE137168: Liaison between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion-Negative Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a pediatric malignancy of mesenchymal origin. Fusion Negative-RMS (FN-RMS...
GSE143361: ALaP-seq and RNA-seq analyses of paraquat treated mESCs
To address the roles of PML bodies in transcription under stress condition, we performed ALaP-seq an...
GSE136898: RNA-seq profiling of in vitro FRC-conditioned, IL6-conditioned or control (anti-CD3/CD28)-stimulated CD8+ T cells
To broadly assess which pathways FRCs regulate in CD8+ T cells, we sorted CD8+ T cells for RNA-seq f...
GSE134373: Whole Transcriptome Sequencing (mRNA-seq) of cultured pulmonary primary endothelial cells treated with or without H2O2
ROS once released from myeloid cells is quickly converted into H2O2 in lungs. We performed RNAseq o...
GSE127815: TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn
Ten-eleven-translocation (TET) proteins catalyze DNA hydroxylation, playing an important role in dem...
GSE135030: Treatment of MEC1, EHEB and JVM2 leukemia cell lines with fludarabine, ibrutinib and idelalisib
UGT2B17 is a recently identified molecular marker for poor prognosis and drug response in Chronic Ly...
GSE141147: Selinexor, a First-in-Class XPO1 Inhibitor, Is Efficacious and Tolerable in Patients with Myelodysplastic Syndromes Refractory to Hypomethylating Agents
PURPOSE The median overall survival (OS) of patients with high-risk myelodysplastic syndromes (MDS)...
GSE137833: Androgen Receptor Degraders Overcome Common Resistance Mechanisms Developed During Prostate Cancer Treatment
RNA-sequencing of VCaP and LNCaP, LNCaP-EnzR, or LNCaP AR-V7 overexpressing prostate cancer cell lin...
GSE154707: m6A-seq profiling in Mettl3 Ctrl and dTAG13 mESCs [m6Aseq]
dTAG-13 treated METTL3_FKBP12(F36V) is sufficient to functionally deplete m6A methylation, that cata...
GSE128513: The Airn RNA does not require any DNA elements within its locus to silence distant imprinted genes
Long non-coding (lnc) RNAs are numerous and found throughout the mammalian genome, and many are thou...
GSE133915: Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]
Obesity is a global rising problem with epidemiological dimension. Obese parents can have programmin...
GSE142670: Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder
Evaluation of expression profile in autism spectrum disorder (ASD) patients is an important approach...
GSE142451: Single-cell CRISPR screening on mouse embryonic stem cells
We performed CROP-seq experiments to interrogate genes that are critical for mouse embryonic stem ce...
GSE135047: Quantitative comparison between cellular mRNAs and exosomal mRNAs in human iPSC-derived motor neurons
The order in the abundance of exosomal mRNAs was not the same with that of the source cellular mRNAs...
GSE135854: Molecular Pathology of Human Knee Arthrofibrosis Defined by RNA Sequencing
This study aims to compare the genetic profile of fibrotic and non-fibrotic human knee capsular tiss...
GSE149153: Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
We used mRNA-seq analysis to explore the transcriptional response induced in BV-2 cells by stable ov...
GSE134388: ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment
We performed RNA-Seq and m6A RNA immunoprecipitation followed by high-throughput sequencing (MeRIP-S...
GSE134521: Gcn5-mediated histone acetylation governs nucleosome dynamics in spermiogenesis [RNA-Seq]
During mammalian spermatogenesis, male germ cells undergo dramatic reorganization of chromatin, wher...
GSE136553: Vimentin knock out mouse neural stem cell RNA sequencing
Total RNA sequencing data generated from untreated wild type (NT) and vimentin knock out (KO) mouse ...
GSE155298: MKL1 global knockout effect on transcriptome of bone marrow derived macropahges
The goal of this project is to determine the critical genes and pathways regulated by MKL1 in bone m...
GSE142485: Gaucher Disease Renders Resistance Against Viral Infection of the CNS
Purpose: In order to describe how non- genetic factors may contribute to emergence of additional neu...
GSE131714: Endocrine-exocrine signaling in obesity-driven pancreatic ductal adenocarcinoma
Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and w...
GSE126645: Antagonistic interaction between Ezh2 and Arid1a coordinates dental root patterning via Cdkn2a [RNA-Seq]
We sequenced mouse molar mRNA from three-day-old Ezh2fl/fl and Osr2KI-Cre;Ezh2fl/fl mice to compare ...
GSE126888: miR-19 protects heart from myocardium infarction
The adult heart has been considered as an organ with limited regenerating capability due to mature c...
GSE142640: Transcriptome analysis of germinal center B cells of WT and SAP-deficient mice
Analysis of germinal center B cells derived from WT and SAP-deficient mice revealed that SAP-deficie...
GSE140490: Discovery of a selective inhibitor of Doublecortin Like Kinase 1
Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of ...
GSE130699: Single nucleus RNA-seq of cardiomyocytes from neonatal mouse hearts after injury
The adult mammalian heart is incapable of regeneration following injury. In contrast, the neonatal m...
GSE136893: Establishment of chronic typhoid infection in a mouse carriage model involves a Type 2 immune shift and T and B cell recruitment to the gallbladder
Typhoid fever, caused primarily by Salmonella enterica serovar Typhi (S. Typhi), is a life-threateni...
GSE126913: Gene expression profiling of neutrophils derived from K14HPV16/H2b and FVBN/H2b mice.
Cancers induced by human papillomaviruses should, in principle, be responsive to immunotherapy by vi...
GSE128561: Glial transcriptome responses to chronic intermittent ethanol exposure
Purpose: Identify the specific transcriptome alterations in astrocytes and microglia isolated from m...
GSE138468: Dosage normalization of the Down syndrome critical causative gene Dyrk1a and Kcnj6
Down syndrome (DS) is the most frequently occurred human chromosomal disorder for mental retardation...
GSE140495: In vivo CRISPR screens reveal NOTCH regulators suppressing Head and Neck Squamous Cell Carcinoma in mice [RNA-seq]
In most cancers, only a few genes are mutated at high frequencies, while the vast majority are mutat...
GSE137136: The impact of pro-inflammatory cytokines on the -cell regulatory landscape provides insights into the genetics of type 1 diabetes
Early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progres...
GSE155437: Transcriptome profile of ZIP7 knockdown cells
We analysed the transcriptome profile by RNA-seq when knockdown ZIP7 by two individual siRNAs in MDA...
GSE133989: NAD+ controls circadian reprogramming through PER2 nuclear translocation to counter aging
Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metaboli...
GSE143882: Gene-expression profiles of HepG2.2.15 cells induced by overexpression of Complement 2
To explore the effect of overexpression of complement component 2 (C2) on HepG2.2.15 cells, we estab...
GSE136534: TGF-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression
Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently be...
GSE127252: Combinational effect of sulforaphane and epigenetic demethylation agent 5-aza-2'-deoxycytidine on metastatic melanoma
Background: UV exposure-induced oxidative stress is implicated as the driving mechanism for melanoma...
GSE147818: DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [RNA-Seq]
Mutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and related disorders, b...
GSE141141: Identification of human endogenous retroviruses working as enhancers in cancer cells
Human endogenous retroviruses (HERVs) are a sort of transposable elements. HERVs harbor abundant reg...
GSE152147: The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma
Glioblastoma is the most common malignant primary brain tumor. Clinically relevant biomarkers are re...
GSE128519: Existence of human-virus chimeric proteins generated during infection
Influenza A virus (IAV) is a threat to mankind because it generates yearly epidemics and poorly pred...
GSE136969: Foxp3+ regulatory T cells mediate glucocorticoid-induced treatment via a miR342-dependent metabolic programming
Glucocorticoids (GC) are the mainstay treatment option for acute and chronic inflammatory conditions...
GSE141945: RNA-seq of Glioblastoma Tumors and GBOs
Analysis of glioblastoma tissue and corresponding glioblastoma organoids by RNA sequencing. SOURCE: ...
GSE136535: Differential gene expression in postnatal day 10 Scn1b+/+ vs. Scn1b -/- cardiac ventricle
Scn1b null mice are a model of a severe developmental and epileptic encephalopathy called Dravet Syn...
GSE130257: Long-term repopulation of Langerhans cell network following immune injury is inefficient and solely dependent upon influx of monocyte precursors
RNAseq gene expression following the repopulation of the langerhans cell network in immune deficien...
GSE59335: Investigation into human Tra2 protein-dependent splicing in MDA-MB-231 cells using iCLIP and RNA-seq
Alternative splicingthe production of multiple mRNA isoforms from a single geneis regulated in part ...
GSE139565: Plasma Cell Fate is Orchestrated by Large-Scale Changes in Compartmentalization
Plasma cell differentiation is characterized by differentiation of progenitor cells into short-lived...
GSE131725: Cyba deficient mice display an increase of Haematopoietic Stem Cells, and a myeloid bias in detriment of B-cell differentiation
The regulation of protein function by reversible oxidation is increasingly recognized as a key mecha...
GSE139346: Ribo-depleted RNA-seq in KRasG12D; p53-null (KP) lung adenocarcinoma cells to measure gene expression changes upon the expression of a T6B-YFP fusion
The identification of miRNA targets by Ago2-CLIP methods has provided major insights into the biolog...
GSE130250: Lineage reprogramming of c-Kit+CD24+ natural killer cells into myeloid cells
Myeloid progenitor cells have generally been considered the exclusive source of myeloid cells under ...
GSE142187: The Adipocyte acquires a Fibroblast-like Transcriptional Signature in response to a High Fat Diet.
RNA-seq analysis of isolated adipocytes after 8, 20 and 34 weeks high fat diet. Our data demonstrate...
GSE139371: Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but the signific...
GSE143342: Gene expression profile of ileum, jejunum and colon in hyperuricemia and wildtype mice
we detected the gen expression of ileum,jejunum and colon in hyperuricemia and wildtype mice SOURCE:...
GSE129257: IRF5 promotes intestinal inflammation by guiding monocyte differentiation towards pathogenic CD11c+ macrophage phenotype [small_bulk_rnaseq]
Mononuclear phagocytes (MNPs) play a key role in maintaining intestinal homeostasis but also in trig...
GSE136451: WDR5 is a conserved regulator of protein synthesis gene expression
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the conte...
GSE136910: RNA Seq of Subcutaneous adipose tissue from endothelial-AGO1-knockout (EC-AGO1-KO) mice and wild-type (WT) littermates
Purpose: to profile transcriptome changes due to EC-AGO1-deficiency; Methods: Subcutaneous adipose t...